Multiple Sclerosis, Nrf2 and Oxidative Stress
What is Multiple Sclerosis?
Multiple Sclerosis (MS) is an autoimmune disease that damages the nerves in the spinal cord and the brain . This damage causes tingling of the nerves or numbness in the body and loss of muscle control. Vision and Balance and vision can also be destructively impacted. Sclerosis is the establishment or buildup of scar tissue in the spine and brain. This buildup destroys the protective covering (myelin) around the nerves. This in turn interrupts the communications between the brain, spinal cord and other areas of the body.
Secondarily, the disease generates inflammatory-mediated reactive oxygen and nitrogen species within the body. Those that study Nuclear factor-erythroid 2-related factor 2 (Nrf2) know this has a negative impact on the production of protective antioxidant and detoxication enzymes within the cells.
The disease affects 400,000 plus Americans according to the WebMD website. Statistically more females are impacted by the disease than males. Prime ages for risk are between 20 and 50 years old.
Multiple Sclerosis Symptoms:
Multiple sclerosis causes many different symptoms, including vision loss, muscle weakness and stiffness, bladder control issues, pain, fatigue and impaired coordination. The symptoms, severity and duration can vary from person to person. Some people may be symptom free for most of their lives, while others can have severe, chronic symptoms that never go away.
NRF2, Oxidative Stress and Multiple Sclerosis Studies
NRF2 activation or balancing may help multiple sclerosis (MS) patients in the following ways.
- NRF2 activation has been shown to reduce fibrosis in the body. Reduction or slowdown of scar tissue creation.
- Increased production of detoxification enzymes and protective antioxidant.
- Nrf2 can modulate an autoimmune neuro-inflammatory response.
- A study published in Pharmacogenomics Journal (June 2012) showed NRF2 treatment worked best when consistently applied as opposed to once off “boost” treatments.
- Production of antioxidant genes regulate inflammatory cytokines and endogenous anti-oxidants which are variables affecting disease progression in multiple sclerosis (MS). In addition they exert neuroprotective effects directly.(See Sci Rep. 2011;1:201. Epub 2011 Dec 19)
Information provided on this site is for educational purposes only. Do your own research, and consult with a medical professional about your findings.
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